anti-EpCAM antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-Epcam antibody; Epcam;
The EpCAM epcam (Catalog #MBS532851) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s EpCAM can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the EpCAM epcam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The EpCAM epcam product has the following accession number(s) (GI #218505670) (NCBI Accession #NP_002345.2) (Uniprot Accession #P16422). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Mouse monoclonal EpCAM antibody.
Biological Significance: EpCAM is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. It has been used as an immunotherapeutic target in the treatment of gastrointestinal, urological and other carcinomas. It is expressed in undifferentiated pluripotent stem cells. Cross-Reactivity: To be determined by the end user
Immunogen: EpCAM antibody was raised in mouse using HT-29 colon carcinoma cell line as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing EpCAM are readily searchable from our website. Different antibodies against the same target such as EpCAM may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Adenocarcinoma, Breast Neoplasms, Carcinoma, Carcinoma, Hepatocellular, Carcinoma, Squamous Cell, Liver Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Experimental, Ovarian Neoplasms are some of the diseases may be linked to EpCAM antibody. Ascites, Blood, Intestine, Kidney, Liver, Lung, Lymph Node, Prostate, Stomach, Vascular tissues are correlated with this protein. EpCAM also interacts with the following gene(s): CCND1, CDH1, CLDN7, GPNMB, MYC, PROM1, PTPRC, TP53, TSPAN8.