|The EPOR epor (Catalog #MBS2544057) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human EPOR Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s EPOR can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).
ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human EPOR. The detection limit for Human EPOR is approximately 0.00245 ng/well. Researchers should empirically determine the suitability of the EPOR epor for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The EPOR epor product has the following accession number(s) (GI #4503591). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type I single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.
Immunogen: Recombinant Human EPOR Protein
Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human EPOR (rh EPOR; Met 1-Pro 250; NP_000112.1). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing EPOR are readily searchable from our website. Different antibodies against the same target such as EPOR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. EPOR also interacts with the following gene(s): CRKL, EPO, GRB2, JAK2, KIT, LYN, STAT5A, STAT5B. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Eye, Heart, Kidney, Liver, Lung, Skin tissues are correlated with this protein. Anemia, Breast Neoplasms, Cardiovascular Diseases, Cell Transformation, Neoplastic, Disease Models, Animal, Inflammation, Kidney Diseases, Necrosis, Neoplasms, Experimental, Polycythemia are some of the diseases may be linked to Rabbit anti Human EPOR Monoclonal Antibody.