|The ErbB-2/HER-2 erbb2 (Catalog #MBS8533248) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-ErbB-2/HER-2 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ErbB-2/HER-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ErbB-2/HER-2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ErbB-2/HER-2 erbb2 product has the following accession number(s) (GI #54792098) (NCBI Accession #NP_001005862.1) (Uniprot Accession #P04626). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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In the nucleus is involved in transcriptional regulation. Associates with the 5\'-TCAAATTC-3\' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC.
Immunogen: Synthetic Peptide
Storage Buffer: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ErbB-2/HER-2 are readily searchable from our website. Different antibodies against the same target such as ErbB-2/HER-2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinoma, Disease Progression, Gastrointestinal Neoplasms, Lymphatic Metastasis, Neoplasm Metastasis, Neoplasms, Neoplasms, Experimental, Skin Diseases are some of the diseases may be linked to Anti-ErbB-2/HER-2 Mouse mAb. ErbB-2/HER-2 also interacts with the following gene(s): CTNNB1, EGF, EGFR, ERBB3, ERBB4, GRB2, GRB7, HLA-A, MUC1, SRC. Blood, Bone, Brain, Heart, Liver, Lung, Lymph Node, Mammary Gland, Prostate, Stomach tissues are correlated with this protein.