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anti-ErbB-2/HER-2 antibody product blog

Posted on 2015-11-04 16:10:57 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; ErbB-2/HER-2; anti-ErbB-2/HER-2 antibody;
The ErbB-2/HER-2 erbb2 (Catalog #MBS9400288) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ErbB-2/HER-2 Mouse Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s ErbB-2/HER-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).
Western blotting: 1:2000~1:4000
Immunohistochemistry: 1:200. Researchers should empirically determine the suitability of the ErbB-2/HER-2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The ErbB-2/HER-2 erbb2 product has the following accession number(s) (GI #54792098) (NCBI Accession #NP_001005862.1) (Uniprot Accession #P04626). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ErbB-2/HER-2 Mouse Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of Hela cell lysate (lane 1) and mouse brain (lane 2), using diluted at 1:4,000.)
Western Blot (WB) ErbB-2/HER-2.

Immunohistochemistry (IHC) (IHC staining of human breast cancer tissue with ErbB-2/HER-2 mouse mAb(11H9) diluted at 1:200.)
Immunohistochemistry (IHC) ErbB-2/HER-2.

ErbB 2 is a receptor tyrosine kinase of the ErbB 2 family. It is closely related instructure to the epidermal growth factor receptor. ErbB 2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.

Target Name: ErbB-2/HER-2. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ErbB-2/HER-2 are readily searchable from our website. Different antibodies against the same target such as ErbB-2/HER-2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinogenesis, Carcinoma, Disease Progression, Gastrointestinal Neoplasms, Lung Neoplasms, Lymphatic Metastasis, Neoplasm Metastasis, Neoplasms, Experimental are some of the diseases may be linked to ErbB-2/HER-2 Mouse Monoclonal Antibody. ErbB-2/HER-2 also interacts with the following gene(s): CTNNB1, EGFR, ERBB2IP, ERBB3, GRB2, HSP90AA1, PTPN11, SHC1, SRC, UBC. Blood, Bone, Brain, Heart, Liver, Lung, Lymph Node, Mammary Gland, Prostate, Stomach tissues are correlated with this protein.
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