|The ERBB3 c-erbb-3 (Catalog #MBS532840) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ERBB3 antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ERBB3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
WB: 1:500-1:2000. Researchers should empirically determine the suitability of the ERBB3 c-erbb-3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ERBB3 c-erbb-3 product has the following accession number(s) (GI #12803739) (NCBI Accession #AAH02706.1) (Uniprot Accession #O75810). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ERBB3 antibody with the following immunoassay(s):
Western Blot (Western Blot analysis using ERBB3 antibody
Western Blot showing ERBB3 antibody used against truncated Trx-ERBB3 recombinant protein (1), MBP-ERBB3 (aa1175-1275) recombinant protein (2) and truncated ERBB3 (aa665-1342)-hIgGFc transfected CH0-K1 cell lysate (3).)
Mouse monoclonal ERBB3 antibody.
Biological Significance: ERBB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Immunogen: ERBB3 antibody was raised in Mouse using a purified recombinant fragment of ERBB3(aa1175-1275) expressed in E Coli as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ERBB3 are readily searchable from our website. Different antibodies against the same target such as ERBB3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. ERBB3 also interacts with the following gene(s): AKT1, EGFR, ERBB2, GRB2, NRG1, NRG2, PA2G4, PIK3R1, RNF41, SHC1. Brain, Embryonic Tissue, Heart, Liver, Lung, Muscle, Nerve, Prostate, Stomach, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.