anti-F8 antibody product blog
Tags: Antibody; Monoclonal Antibody; Factor VIII; anti-F8 antibody;
The F8 f8 (Catalog #MBS219575) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s FACTOR VIII can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Radioimmunoassays (RIA), Western Blot (WB).Western Blotting: Minimum Dilution: 1/100. Researchers should empirically determine the suitability of the F8 f8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The F8 f8 product has the following accession number(s) (GI #4503647) (NCBI Accession #NP_000123.1) (Uniprot Accession #P00451). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MOUSE ANTI HUMAN FACTOR VIII with the following immunoassay(s):
Testing Data (Recombinant Factor VIII probed with Mouse anti Human Factor VIII)
Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/10 recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A, a disorder characterised by the body\'s inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/10 recognizes an epitope within the non-functional, middle domain of full-length Factor VIII.
Perservative Stabilisers: 0.09% Sodium Azide (NaN3)
Preparation: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant. Immunogen: Affinity purified human Factor VIII
Buffer Solution: Phosphate buffered saline
Target Species: Human. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing F8 are readily searchable from our website. Different antibodies against the same target such as F8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. F8 also interacts with the following gene(s): F10, LMAN1, SERPINE1, VWF. The following patways have been known to be associated with this gene.