|The FCN3 fcn3 (Catalog #MBS6003857) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FCN3 (FCNH, HAKA1, Ficolin-3, Collagen/Fibrinogen Domain-containing Lectin 3 p35, Collagen/Fibrinogen Domain-containing Protein 3, Hakata Antigen, MGC22543) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s FCN3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP).
Suitable for use in ELISA, Immunoprecipitation and Western Blot. Researchers should empirically determine the suitability of the FCN3 fcn3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FCN3 fcn3 product has the following accession number(s) (GI #27754778) (NCBI Accession #NP_775628.1) (Uniprot Accession #O75636). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MDLLWILPSL WLLLLGGPAC LKTQEHPSCP GPRELEASKV VLLPSCPGAP GSPGEKGAPG PQGPPGPPGK MGPKGEPGPR NCRELLSQGA TLSGWYHLCL PEGRALPVFC DMDTEGGGWL VFQRRQDGSV DFFRSWSSYR AGFGNQESEF WLGNENLHQL TLQGNWELRV ELEDFNGNRT FAHYATFRLL GEVDHYQLAL GKFSEGTAGD SLSLHSGRPL TTYDADHDSS NSNCAVIVHG AWWYASCYRS NLNGR.
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Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Immunogen: Full length recombinant corresponding to aa1-289 from FCN3 with GST tag. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FCN3 are readily searchable from our website. Different antibodies against the same target such as FCN3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Immunologic Deficiency Syndromes are some of the diseases may be linked to FCN3 (FCNH, HAKA1, Ficolin-3, Collagen/Fibrinogen Domain-containing Lectin 3 p35, Collagen/Fibrinogen Domain-containing Protein 3, Hakata Antigen, MGC22543).