|The Fcnb fcn2 (Catalog #MBS584053) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Ficolin-2, Human, mAb GN4, Biotin reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Ficolin-2 can be used in a range of immunoassay formats including, but not limited to, Immunoassay (IA), Immunoprecipitation (IP).
. Researchers should empirically determine the suitability of the Fcnb fcn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Fcnb fcn2 product has the following accession number(s) (GI #77404440) (NCBI Accession #NP_034320.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Product Description: The monoclonal antibody GN4 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin), and Ficolin-3 (H-ficolin). Ficolin-1, is mainly expressed by monocytes, granulocytes and lung cells and is present locally in areas of inflammation. Ficolin-2 (also L-ficolin, ficolin L, EBP-37 or hucolin) is produced primarily by the liver. The association between Ficolin-2 and MASPs/sMAP is Ca2+-dependent. MASPs in Ficolin-2-MASP complexes have proteolytic activities for C4, C2 and C3. Ficolin-2 also shows opsonic activity.
Conjugate: Biotin. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Fcnb are readily searchable from our website. Different antibodies against the same target such as Fcnb may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Autoimmune Diseases, Immune System Diseases, Lung Diseases, Necrosis are some of the diseases may be linked to Ficolin-2, Human, mAb GN4, Biotin.