|The FES n/a (Catalog #MBS475755) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-FES Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s FES can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the FES n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-FES Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using FES mouse mAb against truncated FES recombinant protein.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human cerebrum tumor (A), endothelium of vessel (B), lymphocyte of thymus (C), showing cytoplasmic localization using FES mouse mAb with DAB staining.)
Entrez Summary: FES (feline sarcoma oncogene) and Fer are the only two members of an unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
Immunogen: Purified recombinant fragment of FES (AA:613-822)expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FES are readily searchable from our website. Different antibodies against the same target such as FES may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.