|The Fig4 fig4 (Catalog #MBS801597) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FIG4/SAC3 Antibody: ATTO 633 reacts with Human, Rat, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s FIG4/SAC3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC).
1:1000 WB. Researchers should empirically determine the suitability of the Fig4 fig4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Fig4 fig4 product has the following accession number(s) (GI #19527220) (NCBI Accession #NP_598760.1) (Uniprot Accession #Q91WF7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Background Info: Detects a 100 kDa protein.
Scientific Background: Fig4/Sac3 phosphatase, a 97-kDa protein, specifically removes the 5-phosphate from the inositol ring of PI(3,5)P2, a membrane-bound phospholipid, which acts as a molecular signal for trafficking and fusion of intracellular vesicles. It is broadly expressed in all eukaryotic cells and plays a vital role in intracellular membrane trafficking and signaling. Mutations in Fig4/Sac3 have been linked to pale tremor mice that exhibit neuropathy with severe central and peripheral neuronal degeneration, including the loss of neurons in the dorsal root ganglion and the sciatic nerve. Fig4/Sac3 knockout mice have been shown to be smaller in size and exhibit abnormal tremor and gait and neuronal autophagy.
Conjugate: ATTO 633. Storage Buffer: PBS pH 7.4, 50% glycerol, 0.1% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Fig4 are readily searchable from our website. Different antibodies against the same target such as Fig4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Kidney, Lung, Other, Skin, Spleen, Thymus tissues are correlated with this protein. Fig4 also interacts with the following gene(s): Mtm1, Mtmr2, Pikfyve, Vac14. The following patways have been known to be associated with this gene. Abnormalities, Multiple, Brain Diseases, Breast Neoplasms, Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth Disease, Type 4j, Congenital Abnormalities, Disease Models, Animal, Kidney Diseases, Nervous System Diseases, Peripheral Nervous System Diseases are some of the diseases may be linked to FIG4/SAC3 Antibody: ATTO 633.