Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Monoclonal Antibody Blog  rightarrow anti-FKBP5 antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • anti-STUB1 antibody blog
 • anti-IL-7 antibody blog
 • anti-Mdc1 antibody blog
 • anti-DUX4L1 antibody blog
 • anti-Panx2 antibody blog
 • anti-HIV-1 nef, aa163-173 antibody blog
 • anti-IL-2 antibody blog
 • anti-IGF-1 Clone 1F-3H10 antibody blog
 • anti-TNFa antibody blog
 • anti-CD23 antibody blog
 • anti-MLKL antibody blog
 • anti-Ephrin-B1 antibody blog
 • anti-Chymotrypsin antibody blog
 • anti-SLC18A3 antibody blog
 • anti-NT-ProBNP antibody blog
 • anti-TLR5 antibody blog
 • anti-SMPDL3B antibody blog
 • anti-NF1P5 antibody blog
 • anti-Neu-Oncogen (C-erb B2) antibody blog
 • anti-CD45RA-SPRD antibody blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • Pro Atrial Natriuretic Peptide (Pro ANP) ELISA Kit
 • Cytosolic Phospholipase A2 (Cpla2) ELISA Kit
 • solute carrier family 7, (cationic amino acid transporter, y... ELISA Kit
 • adenosine deaminase, RNA-specific (ADAR) Antibody
 • Osteocalcin (BGLAP) Antibody
 • CD31 (PECAM1) Antibody
 • Vasopressin Receptor V1a (Avpr1a) Antibody
 • Galanthus Navalis Agglutinin (GNA) ELISA Kit
 • Hemoglobin-Advanced Glycosylation End Products (HB-AGE) ELISA Kit
 • Indoleamine 2,3-dioxygenase 1 (IDO1) ELISA Kit
 • Protein Induced Vitamin K Absence or Antagonist-II (PIVKA-II... ELISA Kit
 • PAK4 (pS474) (PAK4 (pS474)) Antibody
 • Dermatan Sulfate (DS) ELISA Kit
 • Collagen Type IV Alpha 3 (COL4a3) ELISA Kit
 downarrow more ...
separator

anti-FKBP5 antibody product blog

separator
Posted on 2016-01-25 14:39:18 by mybiosource_staff
Share it on ...     
separator
separator
Tags: Antibody; FKBP5; Monoclonal Antibody; anti-FKBP5 antibody; FKBP51;
separator
The FKBP5 fkbp5 (Catalog #MBS800974) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FKBP51 Antibody: Alkaline Phosphatase reacts with Canine, Hamster, Human, Mouse, Rat, Rabbit and may cross-react with other species as described in the data sheet. MyBioSource\'s FKBP51 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF).
1:2000 (WB). Researchers should empirically determine the suitability of the FKBP5 fkbp5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The FKBP5 fkbp5 product has the following accession number(s) (GI #224809327) (NCBI Accession #NP_001139247.1) (Uniprot Accession #Q13451). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the FKBP51 Antibody: Alkaline Phosphatase with the following immunoassay(s):
Testing Data (IF localization of FKBP51 antibody in normal MK cells (shown in red).
Courtesy of the Hospital Henri Mondor, France.)
Testing Data FKBP5.

Testing Data #2 (Western blot analysis of FKBP51 in HeLa cell lysates, using a 1:1000 dilution.)
Testing Data #2 FKBP5.

Background Info: Detects an ~51kDa protein representing FKBP51 in cell lysate. Also detects FKBP51 in whole tissue extracts from rat kidney and rat and mouse testes.

Scientific Background: Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).

horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions