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anti-FKBP5 antibody product blog

Posted on 2016-01-25 14:39:18 by mybiosource_staff
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Tags: Antibody; FKBP5; Monoclonal Antibody; anti-FKBP5 antibody; FKBP51;
The FKBP5 fkbp5 (Catalog #MBS800974) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FKBP51 Antibody: Alkaline Phosphatase reacts with Canine, Hamster, Human, Mouse, Rat, Rabbit and may cross-react with other species as described in the data sheet. MyBioSource\'s FKBP51 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF).
1:2000 (WB). Researchers should empirically determine the suitability of the FKBP5 fkbp5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The FKBP5 fkbp5 product has the following accession number(s) (GI #224809327) (NCBI Accession #NP_001139247.1) (Uniprot Accession #Q13451). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the FKBP51 Antibody: Alkaline Phosphatase with the following immunoassay(s):
Testing Data (IF localization of FKBP51 antibody in normal MK cells (shown in red).
Courtesy of the Hospital Henri Mondor, France.)
Testing Data FKBP5.

Testing Data #2 (Western blot analysis of FKBP51 in HeLa cell lysates, using a 1:1000 dilution.)
Testing Data #2 FKBP5.

Background Info: Detects an ~51kDa protein representing FKBP51 in cell lysate. Also detects FKBP51 in whole tissue extracts from rat kidney and rat and mouse testes.

Scientific Background: Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3). FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids (5).

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