|The Forssman antigen n/a (Catalog #MBS570245) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat anti Forssman antigen reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Forssman antigen can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) (frozen).
117C92 is useful for immuohistochemistry on frozen sections. Optimal antibody dilution should be determined by titRation. Researchers should empirically determine the suitability of the Forssman antigen n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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The Forssman glycolipid is a glycosylceramide possessing a neutral pentasaccharide head group, referred to as the Forssman antigen (Fa) and is a member of the globoseries glycolipid family. Fa has been identified in a number of mammals and exhibits heterogeneity with respect to developmental and cell-type expression among species. Some studies have reported the presence of the Fa in certain Human embryonic and tumor cells. The majority of Human individuals have undetectable levels of Fa. Gastric and colonic tumors from Fa-negative patients, however, contained relatively high levels of Fa. Moreover, compared with normal lung tissue, many lung cancers contained elevated levels of Fa. These observations arouse interest in Fa for a possible role as a Human tumor antigen.
Source Note: The antibody 117C9 is a Rat anti-Forrsman glycosphingolipid (FGL) antibody derived by fusing Mouse myeloma cells with spleen cells from a Rat immunized with Mouse mammary tumors. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Forssman antigen are readily searchable from our website. Different antibodies against the same target such as Forssman antigen may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.