anti-FOXO3/FOXO3A antibody product blog
Tags: Antibody; Monoclonal Antibody; FOXO3/FOXO3A; anti-FOXO3/FOXO3A antibody;
The FOXO3/FOXO3A foxo3 (Catalog #MBS2400891) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-FOXO3/FOXO3A Antibody (clone 1B11) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s FOXO3/FOXO3A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC) Paraffin.IF: 10 ug/ml
IHC-P: 10 ug/ml. Researchers should empirically determine the suitability of the FOXO3/FOXO3A foxo3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The FOXO3/FOXO3A foxo3 product has the following accession number(s) (GI #4503739) (NCBI Accession #NP_001446.1) (Uniprot Accession #O43524). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-FOXO3/FOXO3A Antibody (clone 1B11) with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-FOXO3/FOXO3A antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)
Immunofluorescence (IF) (Immunofluorescence of monoclonal antibody to FOXO3 on HeLa cell. [antibody concentration 10 ug/ml].)
ELISA (EIA) (Detection limit for recombinant GST tagged FOXO3A is approximately 0.03 ng/ml as a capture antibody.)
Transcriptional activator which triggers apoptosis in the absence ofsurvival factors, including neuronal cell death upon oxidative stress.Recognizes and binds to the DNA sequence 5\'-[AG]TAAA[TC]A-3\'.Participates in post-transcriptional regulation of MYC: followingphosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34cexpression, 2 post-transcriptional regulators of MYC that bind to the 3\'UTR of MYC transcript and prevent its translation.
Immunogen: FOXO3A (AAH21224, 361 a.a. ~ 460 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugation: Unconjugated. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing FOXO3/FOXO3A are readily searchable from our website. Different antibodies against the same target such as FOXO3/FOXO3A may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. FOXO3/FOXO3A also interacts with the following gene(s): AKT1, CDKN1A, CDKN1B, CTNNB1, IKBKB, SGK1, SIRT1, SMAD2, SMAD3, TP53.