|The Gria1 gria1 (Catalog #MBS802700) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GluA1/GluR1 Glutamate Receptor Antibody: PE/ATTO 594 reacts with Rat, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s GluA1/GluR1 Glutamate Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC).
1:1000 WB. Researchers should empirically determine the suitability of the Gria1 gria1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Gria1 gria1 product has the following accession number(s) (GI #29789269) (NCBI Accession #NP_113796) (Uniprot Accession #P19490). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Background Info: Detects ~100kDa. Does not cross-react with GluR2.
Scientific Background: Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3).
Conjugate: ATTO 594. Storage Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Gria1 are readily searchable from our website. Different antibodies against the same target such as Gria1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Heart tissues are correlated with this protein. Brain Diseases, Disease Models, Animal, Hypertension, Memory Disorders, Mental Disorders, Nervous System Diseases, Neurobehavioral Manifestations, Poisoning, Prenatal Injuries, Sexual Dysfunctions, Psychological are some of the diseases may be linked to GluA1/GluR1 Glutamate Receptor Antibody: PE/ATTO 594. The following patways have been known to be associated with this gene.