anti-GRK1 antibody product blog
Tags: Antibody; Monoclonal Antibody; GRK1; anti-GRK1 antibody; Rhodopsin Kinase 1;
The GRK1 grk1 (Catalog #MBS600370) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Rhodopsin Kinase 1 (G Protein-Associated Rhodopsin Kinase 1, GRK1) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Rhodopsin Kinase 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot.
Dilution: Western Blot: 1ug/mL. Researchers should empirically determine the suitability of the GRK1 grk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GRK1 grk1 product has the following accession number(s) (GI #4506529) (NCBI Accession #NP_002920.1) (Uniprot Accession #Q15835). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rhodopsin Kinase 1 (G Protein-Associated Rhodopsin Kinase 1, GRK1) with the following immunoassay(s):
Testing Data (Detection of GRK1 with MAB4498. Lysates from human HeLa, mouse Baf-3, and rat L6 cells were resolved by SDS-PAGE. Following electrophoresis, proteins were transferred to an Immobilon-P membrane and immunoblotted with 1 μg/mL anti-GRK1, as described in Protocols for Immunoblotting.)
G protein-coupled receptor kinases (GRKs) are important modulators of G protein-coupled receptor (GPCR) signaling. Receptor phosphorylation by specific GRKs plays a key role in triggering rapid desensitization. The GRK family consists of 7 isoforms that share a central catalytic domain with homology to other serine/threonine kinases. The catalytic domain is flanked by an amino-terminal RGS domain of 183-188 amino acids and a carboxyl-terminus of variable length. GRK1 and GRK7 are members of the rhodopsin kinase or visual GRK subfamily.
Immunogen: E. coli-derived rhGRK1. (aa 343 - 563). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GRK1 are readily searchable from our website. Different antibodies against the same target such as GRK1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Eye tissues are correlated with this protein. The following patways have been known to be associated with this gene. Cardiovascular Diseases, Hypotension, Ischemia, Kidney Failure, Chronic, Kidney Neoplasms, Neoplasms, OGUCHI DISEASE 1, OGUCHI DISEASE 2, Retinal Degeneration, Vascular Diseases are some of the diseases may be linked to Rhodopsin Kinase 1 (G Protein-Associated Rhodopsin Kinase 1, GRK1).