anti-GRP170 antibody product blog
Tags: Antibody; Monoclonal Antibody; GRP170; anti-GRP170 antibody;
The GRP170 n/a (Catalog #MBS190646) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s GRP170 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoblot (IB).ELISA: Confirmed with antibody (1-10ug/ml) binding to Grp170 at 5ug/ml on the solid phase.
Immunoblotting: confirmed with antibody at 1.0-2.0ug/ml. A band of 170kDa is detected. Researchers should empirically determine the suitability of the GRP170 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Grp170 is a major chaperone/stress protein resident in the ER. It is distantly related in sequence to both hsp110 and hsp70 families, but represents the Grp170 stress protein family. Studies have suggested that Grp170 is an important element of the protein processing machinery of the ER. Unlike Hsp110 and Hsp70, Grp170 has two distinct chaperoning domains; a classic beta-sheet peptide binding domain, with some COOH-terminal sequence, and a COOH-terminal alpha-helical domain. Like other members of the Hsp70 superfamily, Grp170 can elicit anti-tumor immune responses most likely by chaperoning antigenic peptide and binding to receptor(s) on antigen-presenting cells (APC).
Antigen: Synthetic peptide sequence derived from human Grp170 (accession no. NP_006389.3). Positive Control: HEK293 cell lysate.
Dilution Instructions: Dilute in PBS or medium that is identical to that used in the assay system. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GRP170 are readily searchable from our website. Different antibodies against the same target such as GRP170 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.