|The GRP170 hyou1 (Catalog #MBS807133) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human GRP170 Monoclonal IgG2aK reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s GRP170 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western Blot: 1:1000. Researchers should empirically determine the suitability of the GRP170 hyou1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GRP170 hyou1 product has the following accession number(s) (NCBI Accession #NP_006389.3) (Uniprot Accession #Q9Y4L1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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GRP170, also known as ORP150, is the largest member of glucose-regulated Antibodys, and acts as a human chaperone Antibody. It is thought to play an important role in Antibody folding and secretion in the ER. Suppression of the Antibody is associated with accelerated apoptosis, therefore having an important cryoprotective role in hypoxia-induced cellular pertubation. This cryopotective role has led to an anti-tumor immune response, which will hopefully lead to therapeutic immunizations against cancers (1). GRP170 has also been shown to bind with dendritic cells and provide the danger signals to induce anti-tumor immune responses (2).
Immunogen: Raised against a synthetic peptide of human GRP170
Immunogen Species: Human. COA: 1 ug/ml was sufficient for detection of GRP170 in 20 ug of HEK293 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Storage Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide
Conjugate: ATTO 680
Cellular Localization: Endoplasmic Reticulum, Endoplasmic Reticulum Lumen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GRP170 are readily searchable from our website. Different antibodies against the same target such as GRP170 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Brain, Connective Tissue, Kidney, Lung, Lymph, Lymph Node, Nerve, Ovary, Prostate tissues are correlated with this protein. Breast Neoplasms, Carcinoma, Hepatocellular, Disease Models, Animal, Fatty Liver, Fibrosis, Inflammation, Kidney Diseases, Liver Diseases, Neoplasms, Experimental, Proteinuria are some of the diseases may be linked to Mouse Anti-Human GRP170 Monoclonal IgG2aK. The following patways have been known to be associated with this gene.