|The GSN gsn (Catalog #MBS2541926) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The GSN Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s GSN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA).
IHC: 1:20-1:1000. Researchers should empirically determine the suitability of the GSN gsn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GSN gsn product has the following accession number(s) (GI #4504165) (NCBI Accession #NP_000168.1) (Uniprot Accession #P06396). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the GSN Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of Human plasma tissue using Gelsolin Monoclonal Antibody at dilution of 1:2000)
Gelsolin (GSN) is an actin binding protein that regulates actin-severing/depolymerizing in a calcium dependent manner, and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa), differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases, such as, acute liver injury, major trauma, myocardial infarction, inflammation, lung injury, rheumatoid arthritis, hemodialysis, multiple sclerosis, Alzheimer\'s disease.
Immunogen: Fusion protein of Gelsolin. Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Conjugation: Unconjugated. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing GSN are readily searchable from our website. Different antibodies against the same target such as GSN may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. GSN also interacts with the following gene(s): APP, CASP3, EGFR, FN1, SRC, TTR. The following patways have been known to be associated with this gene. Adenocarcinoma, Carcinoma, Hepatocellular, Cardiovascular Diseases, Heart Diseases, Inflammation, Liver Diseases, Liver Neoplasms, Neoplasms, Experimental, Nervous System Diseases, Urinary Bladder Neoplasms are some of the diseases may be linked to GSN Monoclonal Antibody. Bladder, Blood, Bone, Brain, Heart, Liver, Lung, Muscle, Nerve, Skin tissues are correlated with this protein.