|The HDAC3 hdac3 (Catalog #MBS850224) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HDAC3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HDAC3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
ELISA: 1/5000 - 1/20000, WB: 1/100-1/2000. Researchers should empirically determine the suitability of the HDAC3 hdac3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HDAC3 hdac3 product has the following accession number(s) (GI #13128862) (NCBI Accession #NP_003874.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the HDAC3 Antibody with the following immunoassay(s):
Testing Data (HDAC3 antibody at 1/2000 dilution interacts with recombinant HDAC3 protein with a MBP tag. Predicted band size: 80Kda. Observed band size: 80Kda.)
Background: Mouse monoclonal IgG to HDAC3.
Relevance: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone acetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Perservative: 0.02% Sodium Azide, 50% glycerol, 1% BSA, PBS, pH7.4. Immunogen: Recombinant full length of human HDAC3.
Cellular Localization: Nucleus
Pathway: transcriptional regulation, cell cycle. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HDAC3 are readily searchable from our website. Different antibodies against the same target such as HDAC3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Nerve, Thyroid tissues are correlated with this protein. Adenocarcinoma, Brain Diseases, Breast Neoplasms, Carcinoma, Hepatocellular, Hypertrophy, Inflammation, Necrosis, Neoplasms, Experimental, Nervous System Diseases, Prostatic Diseases are some of the diseases may be linked to HDAC3 Antibody. HDAC3 also interacts with the following gene(s): CCND1, GTF2I, HDAC4, HDAC5, NCOR1, NCOR2, NR2C1, RELA, TBL1X, YY1.