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anti-HDAC4 antibody product blog

Posted on 2015-10-31 15:23:50 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; HDAC4; anti-HDAC4 antibody;
The HDAC4 hdac4 (Catalog #MBS850929) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HDAC4 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HDAC4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).
WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000
Not yet tested in other applications. Determining optimal working dilutions by titration test. Researchers should empirically determine the suitability of the HDAC4 hdac4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The HDAC4 hdac4 product has the following accession number(s) (GI #153085395) (NCBI Accession #NP_006028.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the HDAC4 Antibody with the following immunoassay(s):
Western Blot (Western blot analysis using HDAC4 mouse mAb against Hela (1), Jurkat (2) cell lysate.)
Western Blot HDAC4.

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Immunogen: Purified recombinant fragment of human HDAC4 expressed in E. Coli.
Species: Mouse IgG1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HDAC4 are readily searchable from our website. Different antibodies against the same target such as HDAC4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. HDAC4 also interacts with the following gene(s): ANKRA2, HDAC3, MEF2C, MEF2D, NCOR2, SUMO1. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Heart, Liver, Lung, Muscle, Prostate, Thyroid tissues are correlated with this protein. Adenocarcinoma, Brachydactyly, Carcinoma, Cardiovascular Diseases, Heart Diseases, Inflammation, Intellectual Disability, Lung Neoplasms, Nervous System Diseases, Vascular Diseases are some of the diseases may be linked to HDAC4 Antibody.
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