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anti-HDAC6 antibody product blog

Posted on 2015-08-14 06:15:16 by mybiosource_staff
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Tags: Antibody; HDAC6; Monoclonal Antibody; anti-HDAC6 antibody;
The HDAC6 hdac6 (Catalog #MBS533384) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HDAC6 antibody reacts with Human, Dog, Rat, Monkey and may cross-react with other species as described in the data sheet. MyBioSource\'s HDAC6 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB).
FC: 1:100
IF: 1:100
WB: 1:1000-2000. Researchers should empirically determine the suitability of the HDAC6 hdac6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The HDAC6 hdac6 product has the following accession number(s) (GI #13128864) (NCBI Accession #NP_006035) (Uniprot Accession #Q9UBN7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the HDAC6 antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant HDAC6 protein (Right) or empty vector (Left) detected with HDAC6 antibody)
Western Blot (WB) HDAC6.

Immunofluorescence (IF) (Immunofluorescent staining of COS7 cells transiently transfected with recombinant HDAC6 protein using HDAC6 antibody)
Immunofluorescence (IF) HDAC6.

Mouse monoclonal HDAC6 antibody.

Biological Significance: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histoneacetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. Immunogen: HDAC6 antibody was raised in mouse using a full length recombinant protein of human HDAC6 (NP_006035) produced in HEK293T cells, as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HDAC6 are readily searchable from our website. Different antibodies against the same target such as HDAC6 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Cardiovascular Diseases, Fibrosis, Immune System Diseases, Inflammation, Lung Diseases, Lung Neoplasms, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to HDAC6 antibody.
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