|The HePTP n/a (Catalog #MBS832758) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HePTP antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HePTP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
WB: 1:5000. Researchers should empirically determine the suitability of the HePTP n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the HePTP antibody with the following immunoassay(s):
Western Blot (WB) ()
Mouse monoclonal HePTP antibody.
Biological Significance: Hematopoietic tyrosine phosphatase (HePTP, PTPN7) belongs to a subgroup of PTPases with two other members, STEP and PCPTP1. HePTP is a 38 kDa class I non-receptor protein tyrosine phosphatase (PTP) that is strongly expressed in T cells. The protein consists of a short, amino-terminal extension that contains a conserved 16-amino acid kinase interaction motif (KIM) and a carboxy-terminal protein tyrosine phosphatase domain. HePTP binds the MAPK family kinases, Erk1/2 and p38 via KIM. Erk phosphorylates HePTP (at Thr45 and Ser72) and HePTP dephosphorylates Erk (at Tyr185). Immunogen: HePTP antibody was raised in Mouse using a recombinant human protein purified from E Coli as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HePTP are readily searchable from our website. Different antibodies against the same target such as HePTP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.