|The Her2 erbb2 (Catalog #MBS9400271) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Her2 Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Her2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).
IHC: 1:200-1:1000. Researchers should empirically determine the suitability of the Her2 erbb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Her2 erbb2 product has the following accession number(s) (GI #54792098) (NCBI Accession #NP_001005862.1) (Uniprot Accession #P04626). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Her2 Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using Her2 mouse mAb against SKBR3 (1) and MCF-7 (2) cell lysate.)
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Immunogen Type: Recombinant protein
Immunogen Description: Purified recombinant fragment of human Her2 expressed in E. Coli. Target Name: Her2. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Her2 are readily searchable from our website. Different antibodies against the same target such as Her2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Her2 also interacts with the following gene(s): CTNNB1, EGFR, ERBB2IP, ERBB3, GRB2, HSP90AA1, PTPN11, SHC1, SRC, UBC.