Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource  rightarrow Monoclonal Antibody Blog  rightarrow anti-HIF-1 beta/ARNT antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
 • anti-MSi-1 antibody blog
 • anti-Progesterone antibody blog
 • anti-Arginylation antibody blog
 • anti-Tenascin III-6, III-7 antibody blog
 • anti-HLA E antibody blog
 • anti-Adam22 antibody blog
 • anti-SOD1 antibody blog
 • anti-MAP1LC3C antibody blog
 • anti-I-Ab antibody blog
 • anti-RSV FUSION PROTEIN antibody blog
 • anti-GST-Tag antibody blog
 • anti-ESCHERICHIA COLI antibody blog
 • anti-SIRT1 antibody blog
 • anti-Myc-Tag antibody blog
 • anti-CACNA1C antibody blog
 • anti-PRL antibody blog
 • anti-DNMT1 antibody blog
 • anti-CD6 antibody blog
 • anti-SAA1 antibody blog
 • anti-CD4 antibody blog
Blog Categories separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
Our Best Sellers moreseparator
 • UXT Antibody
 • Endothelin receptor type A (EDNRA) Antibody
 • RREB1 Antibody
 • Arg ELISA Kit
 • Cellular retinoic acid-binding protein 1 (CRABP1) Recombinant Protein
 • Interleukin 22 (IL22) Recombinant Protein
 • T-box transcription factor TBX1 (Tbx1) Recombinant Protein
 • Polymorphonuclear Elastase, PMN Elastase ELISA Kit
 • Hepatitis B Surface Antigen adw subtype (HBsAg) Recombinant Protein
 • VPS26B Antibody
 • feline sarcoma oncogene (FES) ELISA Kit
 • Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ... ELISA Kit
 • GPR61 cDNA Clone
 • Vitamin D3 (VD3) ELISA Kit
 downarrow more ...

anti-HIF-1 beta/ARNT antibody product blog

Posted on 2018-01-23 22:10:55 by mybiosource_staff
Share it on ...     
Tags: Antibody; Monoclonal Antibody; HIF-1 beta/ARNT; anti-HIF-1 beta/ARNT antibody;
The HIF-1 beta/ARNT arnt (Catalog #MBS2548961) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HIF-1 beta/ARNT Monoclonal Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s HIF-1 beta/ARNT can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF).
WB: 1:1000-2000
IHC: 1:100-200. Researchers should empirically determine the suitability of the HIF-1 beta/ARNT arnt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The HIF-1 beta/ARNT arnt product has the following accession number(s) (GI #309747071) (NCBI Accession #NP_001184254.1) (Uniprot Accession #P27540). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response to hypoxia (1). The HIF1 complex consists of two subunits, HIF-1alpha and HIF-1beta, which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family (2). HIF1 regulates the transcription of a broad range of genes that facilitate responses to the hypoxic environment, including genes regulating angiogenesis, erythropoiesis, cell cycle, metabolism and apoptosis. The widely expressed HIF-1alpha is typically degraded rapidly in normoxic cells by the ubiquitin/proteasomal pathway. Under normoxic conditions, HIF-1alpha is proline hydroxylated leading to a conformational change that promotes binding to the von Hippel Lindau protein (VLH) E3 ligase complex; ubiquitination and proteasomal degradation follows (3, 4). Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1alpha degradation and lead to its stabilization. In addition, HIF-1alpha can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway (5-7).HIF-1beta is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex (8). Together with AhR, HIF-1beta plays an important role in xenobiotics metabolism (8). In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia (9). Studies also found that ARNT/HIF-1beta expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1beta plays an important role in pancreatic beta-cell function (10).

HIF-1 beta/ARNT arnt

Immunogen: Recombinant Protein
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HIF-1 beta/ARNT are readily searchable from our website. Different antibodies against the same target such as HIF-1 beta/ARNT may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions