|The HIRA hira (Catalog #MBS417790) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-HIRA Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s HIRA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the HIRA hira for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The HIRA hira product has the following accession number(s) (GI #47678537) (NCBI Accession #CAG30389.1) (Uniprot Accession #P54198). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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HIRA is the human homologue of two cell cycle-regulated repressors of histone gene expression in Saccharomyces cerevisiae, Hir1p and Hir2p. In yeast, Hir1p and Hir2p control histone gene expression through the cell cycle. In human cells, HIRA contributes to formation of transcriptionally-repressive heterochromatin in senescent cells and also has roles in transcription-coupled chromatin assembly.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing HIRA are readily searchable from our website. Different antibodies against the same target such as HIRA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. HIRA also interacts with the following gene(s): ASF1A, ASF1B, ATAD2B, CCNA2, CHAF1B, HIRIP3. Blood, Bone, Brain, Heart, Intestine, Kidney, Liver, Lung, Muscle, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. Abnormalities, Multiple, Anemia, Congenital Abnormalities, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Disease Models, Animal, Fibrosis, Inflammation, Liver Diseases, Necrosis, Neurologic Manifestations are some of the diseases may be linked to Anti-HIRA Antibody.