anti-Hydroxyguanosine 8 antibody product blog
Tags: Antibody; Monoclonal Antibody; Hydroxyguanosine 8; anti-Hydroxyguanosine 8 antibody;
The Hydroxyguanosine 8 n/a (Catalog #MBS600087) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Hydroxyguanosine 8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA).Suitable for use in ELISA
Dilution: ELISA: 0.1-5ug/ml. Researchers should empirically determine the suitability of the Hydroxyguanosine 8 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Reactive oxygen species (ROS) are formed at high levels as by-products of the normal cellular metabolism. Both nuclear and mitochondrial DNA has been shown to accumulate high levels of 8-hydroxy-2\'-deoxyguanosine, a very stable and damaging product of hydroxylation of guanine at carbon 8. 8-hydroxyguanosine (8-OHG) induces transversion of G to T, which is potentially mutagenic. The base excision repair (BER) pathway is the most important cellular protection mechanism responding to oxidative DNA damage. They remove modified DNA bases before they are incorporated into DNA during replication. The key enzymes MutT homologs (MutT/MTH) in the BER process are DNA glycosylases, which remove different damaged bases by cleavage of the N-glycosylic bonds between the bases and the deoxyribose moieties of the nucleotide residues. The 8-oxoG glycosylases (Fpg or MutM/OGG) and the MutY homologs (MutY/MYH) glycosylases along with MutT/MTH protect cells from the mutagenic effects of 8-oxoG. 8-hydroxyguanosine (8-OHG) has been used as oxidative stress marker.
Immunogen: 8-OHG (BSA and casein coupled). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Hydroxyguanosine 8 are readily searchable from our website. Different antibodies against the same target such as Hydroxyguanosine 8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.