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anti-ICAM1  antibody product blog

Posted on 2017-03-03 15:43:21 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; ICAM1 ; anti-ICAM1  antibody;
The ICAM1  icam1 (Catalog #MBS2543949) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human ICAM1  Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s ICAM1  can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).
ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human ICAM1. The detection limit for Human ICAM1 is approximately 0.0195 ng/well. Researchers should empirically determine the suitability of the ICAM1  icam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The ICAM1  icam1 product has the following accession number(s) (GI #167466198). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1 (integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

ICAM1  icam1

Immunogen: Recombinant Human ICAM-1 protein
Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human ICAM-1/CD54 (rh ICAM-1/CD54; NP_000192.2; Met 1-Glu 480). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ICAM1  are readily searchable from our website. Different antibodies against the same target such as ICAM1  may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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