anti-IFITM3 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-IFITM3 antibody; IFITM3;
The IFITM3 ifitm3 (Catalog #MBS9217072) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The IFITM3 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s IFITM3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).WB:~~1:4000. Researchers should empirically determine the suitability of the IFITM3 ifitm3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IFITM3 ifitm3 product has the following accession number(s) (GI #148612842) (NCBI Accession #NP_066362.2) (Uniprot Accession #Q01628). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the IFITM3 Antibody (N-term) with the following immunoassay(s):
Western Blot (WB) (All lanes : Anti-Fragilis (IFITM3) Antibody (N-term) at 1:4000 dilution
Lane 1: NCI-H460 whole cell lysate
Lane 2: HepG2 whole cell lysate
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 15 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.)
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
Subtitle: Purified Mouse Monoclonal Antibody (Mab)
Cellular Location: Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Antigen Type: Recombinant Protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IFITM3 are readily searchable from our website. Different antibodies against the same target such as IFITM3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.