anti-IKBKB antibody product blog
Tags: Antibody; Monoclonal Antibody; IKBKB; anti-IKBKB antibody;
The IKBKB ikbkb (Catalog #MBS475725) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-IKBKB Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s IKBKB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the IKBKB ikbkb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The IKBKB ikbkb product has the following accession number(s) (GI #146424317) (NCBI Accession #AAI41979.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-IKBKB Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using IKBKB mouse mAb against truncated IKBKB recombinant protein (1).)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human colon carcinoma (A), breast carcinoma (B), kidney cell carcinoma (C), bladder carcinoma tumor (D), showing membrane and cytoplasmic localization using IKBKB mouse mAb with DAB staining.)
Entrez Summary: IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.
Immunogen: Purified recombinant fragment of IKBKB expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IKBKB are readily searchable from our website. Different antibodies against the same target such as IKBKB may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Atherosclerosis, Breast Neoplasms, Cell Transformation, Neoplastic, Disease Models, Animal, Inflammation, Insulin Resistance, Liver Diseases, Lung Neoplasms, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to Anti-IKBKB Mouse mAb.