|The IKK-y n/a (Catalog #MBS588008) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IKK-y can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC).
Optimal dilution has to be determined by the user. Researchers should empirically determine the suitability of the IKK-y n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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Background: IKK-gamma, also known as NF-kappa-B essential modulator (NEMO) and inhibitor of nuclear factor kappa-B kinase subunit gamma, is the regulatory subunit of the cytoplasmic IkB kinase (IKK) complex. IKK- is required for activation of the IKK complex by upstream components of the NF-kB cascade. The IKK complex activates NF-kB which is an ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. In the cytoplasm, NFkB is maintained in an inactive form by the inhibitory protein IkB. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB, releasing NF-kB dimers. NF-kB dimers subsequently translocate to the nucleus and activate target genes. IKK- interacts preferentially with IKK and is required for activation of IKK complex. Recent studies suggest that IKK gamma (NEMO) may be a key molecule acting as an adapter for onco-protein specific signaling to IKKa and IKKb.
Description: A sensitive antibody against splice variant form of zebrafish IKK. The antibody is in a protein-free culture medium.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IKK-y are readily searchable from our website. Different antibodies against the same target such as IKK-y may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.