anti-IL-11 antibody product blog
Tags: Antibody; IL-11; Monoclonal Antibody; anti-IL-11 antibody;
The IL-11 il11 (Catalog #MBS691010) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human IL-11 reacts with Human and may cross-react with other species as described in the data sheet.ELISA: In a sandwich ELISA (assuming 100ul/well), a concentration of 8-9 ug/ml of this antibody will detect at least 0.2 ng/well of recombinant human IL-11 when used with PeproTech\'s biotinylated antigen affinity purified anti-human IL-11 as the detection antibody at a concentration of at least 2ug/ml. Researchers should empirically determine the suitability of the IL-11 il11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL-11 il11 product has the following accession number(s) (GI #10834994) (NCBI Accession #NP_000632.1) (Uniprot Accession #P20809). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Interleukin 11 (IL-11), also known as adipogenesis inhibitory factor (AGIF), has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. IL-11 exerts its biological activities through binding to a specific high-affinity receptor complex consisting of an IL-11 receptor chain and gp130.
Antibody Generation: Monoclonal antibodies were produced in BALB/c x C57BL/6F1, mice using recombinant human IL-11 as the immunizing antigen. IgG1 antibody was purified from ascites fluid on a Protein An affinity column. Buffer: none
Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hIL-11 (5.0 ng/ml), a concentration of 2.4 - 3.6ug/ml of this antibody is required. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IL-11 are readily searchable from our website. Different antibodies against the same target such as IL-11 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Anemia, Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Hemorrhage, Immune System Diseases, Inflammation, Lung Diseases, Necrosis, Neoplasms are some of the diseases may be linked to Mouse Anti-Human IL-11. Brain, Connective Tissue, Embryonic Tissue, Intestine, Kidney, Pancreas, Prostate, Skin, Stomach, Vascular tissues are correlated with this protein. IL-11 also interacts with the following gene(s): APP, IL11RA, IL6ST, JAK2, PTGS2, STAT3, TNFSF11, TYK2. The following patways have been known to be associated with this gene.