anti-IL-36R antibody product blog
Tags: Antibody; Monoclonal Antibody; IL-36R; anti-IL-36R antibody;
The IL-36R il1rl2 (Catalog #MBS668412) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to IL-36R (Clone: ABM47A2) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s IL-36R can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Flow Cytometry (FC).WB: 2-4 ug/ml
FC: 0.5-1ug/^106 Cells. Researchers should empirically determine the suitability of the IL-36R il1rl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL-36R il1rl2 product has the following accession number(s) (GI #90110768) (NCBI Accession #Q9HB29.2) (Uniprot Accession #Q9HB29). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Monoclonal Antibody to IL-36R (Clone: ABM47A2) with the following immunoassay(s):
Western Blot (WB) (Fig-1: Western blot analysis of IL-36R. Anti-IL-36R antibody (Clone: ABM47A2) was tested at 2 ug/ml on human Small Intestine lysate.)
Flow Cytometry (FC) (Figure-2: Intracellular Flow cytometric analysis of IL-36R in K562 cells using 0.5 �g/10^6 Cells of IL-36R antibody (Clone: ABM47A2). Green represent isotype control and red represent Anti- IL36R antibody. (MBS668412). Goat Anti-Mouse PE conjugated was used as secondary antibody.)
IL-36R is a member of the IL-1 receptor family that has been associated with various inflammation-associated diseases. Ligands binding to IL-36R subsequently recruit the IL-1RAcP (IL-1 Receptor Accessory Protein) forming a heterodimeric signaling complex. The latter is also used by IL-1Alpha and IL-1Beta. IL-36R is expressed by different immune cells, including Dendritic Cells, microglia and other myeloid cells. IL-36 stimulation of DC leads to the production of several cytokines by DC, including TNF-a, IL-1, IL-12, and IL-23. This interaction also enhances the expression of MHC class 2 and co-stimulatory molecules.
Immunogen Information: A partial length recombinant IL-36R protein (amino acids 1-203) was used as the immunogen for this antibody. Antigen: IL-36R. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IL-36R are readily searchable from our website. Different antibodies against the same target such as IL-36R may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.