anti-IL6R antibody product blog
Tags: Antibody; Monoclonal Antibody; IL6R; anti-IL6R antibody; Interleukin 6 Receptor, gp80;
The IL6R il6r (Catalog #MBS603828) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Interleukin 6 Receptor, gp80 (CD126, IL-6R) (Biotin) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Interleukin 6 Receptor, gp80 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS).Suitable for use in Flow Cytometry and Functional Studies.
Dilution: Flow Cytometry: 0.2ug/10e6 cells.
Fuctional Studies: 10ng neutralizes 1 unit of I8428-39K1 on XG1 cells. Inhibition of proliferation by 50%. Researchers should empirically determine the suitability of the IL6R il6r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL6R il6r product has the following accession number(s) (GI #31317249) (NCBI Accession #NP_852004.1) (Uniprot Accession #P08887). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity.
Immunogen: CHO cells transfected with cDNA corresponding to the gp80 IL-6 receptor gene. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IL6R are readily searchable from our website. Different antibodies against the same target such as IL6R may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. IL6R also interacts with the following gene(s): CNTF, IL6, IL6ST, JAK1, JAK2, SOCS3, STAT1, STAT3. Blood, Bone, Bone Marrow, Brain, Heart, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Arthritis, Rheumatoid, Carcinoma, Hepatocellular, Cardiovascular Diseases, Heart Diseases, Hematologic Diseases, Immune System Diseases, Inflammation, Necrosis, Neoplasms, Nervous System Diseases are some of the diseases may be linked to Interleukin 6 Receptor, gp80 (CD126, IL-6R) (Biotin).