anti-INS antibody product blog
Tags: Antibody; Insulin; INS; Monoclonal Antibody; anti-INS antibody;
The INS ins (Catalog #MBS395307) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Insulin reacts with Human, Bovine, Porcine and may cross-react with other species as described in the data sheet. MyBioSource\'s Insulin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the INS ins for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The INS ins product has the following accession number(s) (GI #4557671) (NCBI Accession #NP_000198.1) (Uniprot Accession #P01308). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with full-length insulin protein and mouse myeloma cells. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing INS are readily searchable from our website. Different antibodies against the same target such as INS may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Diabetes Mellitus, Diabetes Mellitus, Type 2, Fatty Liver, Hyperglycemia, Hyperinsulinism, Hypertension, Insulin Resistance, Metabolic Diseases, Obesity, Polycystic Ovary Syndrome are some of the diseases may be linked to Insulin. INS also interacts with the following gene(s): AKT1, AKT2, FOXO1, GRB2, IDE, IGFBP1, INSR, IRS1, IRS2, PTPN1. Blood, Bone, Brain, Heart, Kidney, Liver, Muscle, Nerve, Pancreas, Vascular tissues are correlated with this protein.