|The INS ins (Catalog #MBS9200552) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The INS Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s INS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).
WB~~1:100~500. Researchers should empirically determine the suitability of the INS ins for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The INS ins product has the following accession number(s) (GI #4557671) (NCBI Accession #NP_000198.1) (Uniprot Accession #P01308). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the INS Antibody with the following immunoassay(s):
Western Blot (WB) (INS Antibody western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the INS antibody detected the INS protein (arrow).)
After removal of the precursor signal peptide, proinsulin
is post-translationally cleaved into three peptides: the B chain
and A chain peptides, which are covalently linked via two disulfide
bonds to form insulin, and C-peptide. Binding of insulin to the
insulin receptor (INSR) stimulates glucose uptake. A multitude of
mutant alleles with phenotypic effects have been identified. There
is a read-through gene, INS-IGF2, which overlaps with this gene at
the 5\' region and with the IGF2 gene at the 3\' region. Alternative
splicing results in multiple transcript variants. [provided by
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing INS are readily searchable from our website. Different antibodies against the same target such as INS may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. INS also interacts with the following gene(s): AKT1, FOXO1, IGF1R, IGFBP1, INSR, IRS1, IRS2, PDX1. Diabetes Mellitus, Diabetes Mellitus, Type 2, Hyperglycemia, Hyperinsulinism, Hypertension, Hypoglycemia, Insulin Resistance, Metabolic Diseases, Obesity, Polycystic Ovary Syndrome are some of the diseases may be linked to INS Antibody. Blood, Bone, Brain, Heart, Kidney, Liver, Muscle, Nerve, Pancreas, Vascular tissues are correlated with this protein.