|The Integrin, beta3 n/a (Catalog #MBS608091) is an Antibody produced from Hamster and is intended for research purposes only. The product is available for immediate purchase. The Integrin, beta3 (ITGB3, CD61, GP3A, GPIIIa, HPA-1, NAIT, Platelet Fibrinogen Receptor beta Subunit, Platelet Glycoprotein IIIa, Platelet Membrane Glycoprotein IIIa) reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Integrin, beta3 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Flow Cytometry (FC/FACS).
Suitable for use in Flow Cytometry, Functional Assays, and Immunoprecipitation.
Dilution: Flow Cytometry: 1:25-1:50; 10ul labels 10e6 cells in 100ul. Researchers should empirically determine the suitability of the Integrin, beta3 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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The murine integrin beta 3 subunit (CD61), a 90kD a type I membrane protein, is expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptors for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin.
Immunogen: Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4. Hybridoma: P3U1 mouse myeloma cells with spleen cells from Armenian hamsters. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Integrin, beta3 are readily searchable from our website. Different antibodies against the same target such as Integrin, beta3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.