anti-IRS1 antibody product blog
Tags: Antibody; IRS-1; Monoclonal Antibody; IRS1; anti-IRS1 antibody;
The IRS1 irs1 (Catalog #MBS609061) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IRS-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA).Suitable for use in Indirect ELISA.
Dilution: Indirect ELISA: 1-2ug/ml. Researchers should empirically determine the suitability of the IRS1 irs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IRS1 irs1 product has the following accession number(s) (GI #5031805) (NCBI Accession #NP_005535.1) (Uniprot Accession #P35568). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the IRS-1, phosphorylated (Ser616) (Insulin Receptor Substrate 1, IRS1) with the following immunoassay(s):
ELISA (EIA) (Indirect ELISA Serial dilution of the antibody starting with 5ug/well was done to check for the affinity. 1 μg of coated antigen can be sensitively detected by anti-human IRS Ser 616-Phospho antibody used at 300 pg/well concentration.)
Insulin receptor substrates (IRS) subtypes are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. The balance between Ser/Thr phosphorylation of IRS has been demonstrated to be an important regulator of insulin signaling. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm\'s tumors, and adrenal cortical carcinomas. Does not recognize IRS peptide NOT phosphorylated at Ser616 and will not recognize IRS peptide phosphorylated at Tyr183. Also does not react with riboflavin carrier protein which is known to have multiple phosphate groups.
Immunogen: Synthetic peptide corresponding to IRS-1, phosphorylated at Ser616 site. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing IRS1 are readily searchable from our website. Different antibodies against the same target such as IRS1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. IRS1 also interacts with the following gene(s): AKT1, GRB2, IGF1R, INSR, JAK2, MAPK1, MTOR, PTPN11, SHC1, SOCS3. Breast Neoplasms, Diabetes Mellitus, Type 2, Fatty Liver, Hyperinsulinism, Hypertension, Inflammation, Insulin Resistance, Necrosis, Neoplasms, Obesity are some of the diseases may be linked to IRS-1, phosphorylated (Ser616) (Insulin Receptor Substrate 1, IRS1).