|The ITGA3 itga3 (Catalog #MBS690447) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human Integrin alpha 3 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Integrin alpha 3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) - Formalin, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the ITGA3 itga3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ITGA3 itga3 product has the following accession number(s) (GI #4504747) (NCBI Accession #NP_002195.1) (Uniprot Accession #P26006). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.
Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Integrin a3 (also called CD49c). Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ITGA3 are readily searchable from our website. Different antibodies against the same target such as ITGA3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. ITGA3 also interacts with the following gene(s): FN1, ITGB1, ITGB4, ITGB5, LAMA3, LAMA5, LAMB3, RELN, VTN. Breast Neoplasms, Cell Transformation, Neoplastic, Congenital Abnormalities, Kidney Diseases, Lung Neoplasms, Neoplasms, Nervous System Diseases, Nervous System Malformations, Neural Tube Defects, Neurobehavioral Manifestations are some of the diseases may be linked to Mouse Anti-Human Integrin alpha 3.