|The ITGB3 n/a (Catalog #MBS602982) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Integrin alphaV, beta3 (Biotin) reacts with Avian, Bovine, Canine, Chicken, Human, Monkey, Porcine, Rabbit and may cross-react with other species as described in the data sheet. MyBioSource\'s Integrin alphaV, beta3 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Immunofluorescence (IF).
Suitable for use in Immunoprecipitation, Immunofluorescence,, and Inhibitition. Not suitable for immunohistochemical staining of paraffin-embedded tissue sections.
Dilution: Inhibition: Inhibits adhesion of cells to vitronectin coated surfaces at 10-25ug/ml
Optimal dilutions to be determined by researcher.
Storage and Stability:
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Researchers should empirically determine the suitability of the ITGB3 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ITGB3 n/a product has the following accession number(s) (GI #47522830) (NCBI Accession #NP_999167.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. Due to its involvement in angiogenesis, the integrin aVb3 receptor is one of the most intensely studied of the integrin receptors.
Immunogen: Purified adhesion receptor from the human melanoma cell line M21. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ITGB3 are readily searchable from our website. Different antibodies against the same target such as ITGB3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.