|The Kcnk3 kcnk3 (Catalog #MBS801887) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TASK1 Potassium Channel Antibody: ATTO 655 reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s TASK1 Potassium Channel can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC).
1:1000 WB. Researchers should empirically determine the suitability of the Kcnk3 kcnk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Kcnk3 kcnk3 product has the following accession number(s) (GI #15431283) (NCBI Accession #NP_203694.1) (Uniprot Accession #O54912). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Background Info: Detects a 50 kDa protein. Does not cross-react with TASK3.
Scientific Background: K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions and include TWIK, TREK, TRAAK and TASK. TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54% identity with TASK-1, but less than 30% identity with TASK-2 and other tandem pore K+ channels.
Conjugate: ATTO 655. Storage Buffer: PBS pH 7.4, 50% glycerol, 0.1% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Kcnk3 are readily searchable from our website. Different antibodies against the same target such as Kcnk3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Arrhythmias, Cardiac, Central Nervous System Diseases, Disease Models, Animal, Heart Diseases, Hypertension, Inflammation, Lung Diseases, Nervous System Diseases, Pain, Stroke are some of the diseases may be linked to TASK1 Potassium Channel Antibody: ATTO 655. The following patways have been known to be associated with this gene. Adipose Tissue, Brain, Heart, Nerve, Ovary tissues are correlated with this protein.