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anti-Kir6.1 antibody product blog

Posted on 2016-04-25 21:50:16 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; Kir6.1; anti-Kir6.1 antibody;
The Kir6.1 kcnj8 (Catalog #MBS807057) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Rat Kir6.1 Monoclonal IgG2A reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Kir6.1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF).
Western Blot: 1:1000. Researchers should empirically determine the suitability of the Kir6.1 kcnj8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The Kir6.1 kcnj8 product has the following accession number(s) (GI #148747200) (NCBI Accession #NP_058795.3) (Uniprot Accession #Q63664). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Anti-Rat Kir6.1 Monoclonal IgG2A with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of Rat Brain showing detection of ~45 kDa Kir6.1 protein using Mouse Anti-Kir6.1 Monoclonal Antibody, Clone S366-60. Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 ug. Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-Kir6.1 Monoclonal Antibody at 1:1000 for 16 hours at 4 degree C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~45 kDa. Other Band(s): ~100 kDa.)
Western Blot (WB) Kir6.1.

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family (1-3). This is predominantly detected in fetal and adult hearts, and defects can be associated with J-wave syndromes, a group of heart disorders characterized by early repolarization events (4).

Immunogen: Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
Immunogen Species: Rat. COA: A 1:100 dilution was sufficient for detection of Kir6.1 in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Storage Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide
Conjugate: PerCP
Cellular Localization: Membrane. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Kir6.1 are readily searchable from our website. Different antibodies against the same target such as Kir6.1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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