anti-KLF4 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-KLF4 antibody; KLF4;
The KLF4 klf4 (Catalog #MBS9400038) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The KLF4 Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s KLF4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the KLF4 klf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The KLF4 klf4 product has the following accession number(s) (GI #21410813) (NCBI Accession #AAH30811). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the KLF4 Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of KLF4 in mouse liver tissue lysate with KLF4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
KLF4 is a transcription factor that functions as both a transcriptional activator and repressor to regulate proliferation and differentiation of multiple cell types. The role of KLF4 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing KLF4 and the transcription factors POU5F1, Sox2, and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing KLF4, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. KLF4 interacts directly with POU5F1 and Sox2 in iPS and ES cells and activates the target gene NANOG.
Immunogen Type: Peptide
Immunogen Description: Raised against a 20 amino acid peptide near the carboxy terminus of human KLF4. Target Name: KLF4. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing KLF4 are readily searchable from our website. Different antibodies against the same target such as KLF4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.