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anti-kmt2a antibody product blog

Posted on 2016-06-16 08:07:56 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; KMT2A; anti-KMT2A antibody; MLL;
The kmt2a mll (Catalog #MBS190884) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s MLL can be used in a range of immunoassay formats including, but not limited to, Immunoblot (IB), Immunoprecipitation (IP).
Immunoblotting: Use at 2ug/ml. A band of ~300kDa is detected.
Immunoprecipitation: Use 2-10ug per 500ul (1-3mg/ml) of cell lysate. Researchers should empirically determine the suitability of the kmt2a mll for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The kmt2a mll product has the following accession number(s) (GI #3309543) (NCBI Accession #AAC41377.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-MLL N-Terminus Monoclonal Antibody with the following immunoassay(s):
Testing Data
Testing Data kmt2a.

MLL (Mixed Lineage Leukemia) is a protooncogene that is mutated in a variety of acute leukemias. MLL is proteolytically processed into 2 fragments, MLLN and MLLC, that display opposite transcriptional properties. Processed MLLN and MLLC associate with each other via N-terminal and C-terminal intramolecular interaction domains. MLL processing occurs rapidly after translation and its followed by phosphorylation of MLLC. MLLN displays transcriptional repression activity, whereas MLLC has strong transcriptional activation properties. Leukemia-associated MLL fusion proteins lack the MLL processing sites, do not undergo cleavage, and are unable to interact with MLLC. These observations suggest that posttranslational modifications of MLL may be involved in regulating MLL activity as a transcription factor, and this aspect of its function is perturbed by leukemogenic fusions.

Antigen: Maltose-binding fusion protein containing MLL amino acids 161-356 (Uniprot #Q03164). Positive Control: K562 cell lysate.
Dilution Instructions: Dilute in PBS or medium that is identical to that used in the assay system. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing kmt2a are readily searchable from our website. Different antibodies against the same target such as kmt2a may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.
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