|The KRT18 krt18 (Catalog #MBS9215420) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Keratin 18 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Keratin 18 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC).
WB ~~ 1:2000
ICC ~~ 1:800. Researchers should empirically determine the suitability of the KRT18 krt18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The KRT18 krt18 product has the following accession number(s) (GI #4557888) (NCBI Accession #NP_000215.1) (Uniprot Accession #P05783). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Keratin 18 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot detection of Keratin 18 in Hela,COS7 and 293T cell lysates using Keratin 18 mouse mAb (1:2000 diluted).Predicted band size:46KDa.Observed band size:46KDa.)
Immunocytochemistry (ICC) (Immunocytochemistry staining of HeLa cells fixed by anhydrous methanol for 2 h at -20 degree C and using anti-Keratin 18 mouse mAb (dilution 1:800).)
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Antigen Source: Human. Antigen Type: Recombinant Protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing KRT18 are readily searchable from our website. Different antibodies against the same target such as KRT18 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Eye, Kidney, Liver, Lymph, Lymph Node, Muscle, Prostate, Stomach tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Fatty Liver, Fibrosis, Inflammation, Liver Cirrhosis, Liver Diseases, Necrosis, Neoplasm Metastasis are some of the diseases may be linked to Keratin 18 Antibody. KRT18 also interacts with the following gene(s): CASP6, EGR1, KRT8, TCHP.