|The KSHV ORF45 n/a (Catalog #MBS830183) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s KSHV ORF45 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunocytochemistry (ICC), Western Blot (WB).
WB: 1:500-1:2000. Researchers should empirically determine the suitability of the KSHV ORF45 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the KSHV ORF45 antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot showing KSHV ORF45 antibody used against KSHV ORF45 recombinant protein.)
Mouse monoclonal KSHV ORF45 antibody.
Biological Significance: Kaposi\'s sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi?s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman?s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Immunogen: KSHV ORF45 antibody was raised in Mouse using a purified recombinant fragment of KSHV ORF45 expressed in E Coli as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing KSHV ORF45 are readily searchable from our website. Different antibodies against the same target such as KSHV ORF45 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.