anti-lasB antibody product blog
Tags: Antibody; Monoclonal Antibody; Elastase; anti-lasB antibody; lasB;
The Elastase lasb (Catalog #MBS584075) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Elastase, Human, mAb 265-3K1 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Elastase can be used in a range of immunoassay formats including, but not limited to, Immunoassay (IA), Western Blot (WB).Application Use: For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Researchers should empirically determine the suitability of the Elastase lasb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Elastase lasb product has the following accession number(s) (GI #151212) (NCBI Accession #AAA25811.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Product Description: The monoclonal antibody 265-3K1 recognizes human leukocyte elastase. Leukocyte elastase, a major serine proteinase in man, is predominantly present in the azurophilic granules of neutrophils and monocytes. Elastase has a broad range of extracellular matrix substrates including elastin, proteoglycans, collagen and fibronectin. The action of elastase is controlled by serine proteinase inhibitors. Elastase, when released during inflammation, is rapidly bound by its two main inhibitors, alpha1-PI and alpha2-macroglobuline to form elastase-inhibitor complexes. In addition mucosa secretions may contain the locally secreted elastase inhibitors elafin/SKALP and SLPI. When secreted at sites of inflammation elastase can cause severe tissue damage. An important role has been suggested for human elastase in various inflammatory disorders, including pulmonary emphysema, sepsis, arthritis, nephritis and certain skin diseases. Elastase induces the production of IL-8 in human bronchial epithelial, a proces that occurs in part through TLR4.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Elastase are readily searchable from our website. Different antibodies against the same target such as Elastase may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.