anti-LIME1 antibody product blog
Tags: Antibody; Monoclonal Antibody; Lime1; anti-LIME1 antibody; Lck Interacting Molecule;
The LIME1 lime1 (Catalog #MBS631685) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Lck Interacting Molecule (Lck-interacting Molecule, LIME, LIME1, dJ583P15.4, FLJ20406, Lck Interacting Transmembrane Adaptor 1, Lck-interacting Transmembrane Adapter 1, Lck-interacting Membrane Protein, LP8067, RP4-583P15.5) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Lck Interacting Molecule can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP).Suitable for use in Immunoprecipitation. Researchers should empirically determine the suitability of the LIME1 lime1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The LIME1 lime1 product has the following accession number(s) (GI #157388906) (NCBI Accession #NP_060276.2) (Uniprot Accession #Q9H400). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
LIME (Lck-interacting molecule) is a new raft-associated adaptor protein involved in regulation of T cell activation by coreceptors. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation.
Immunogen: Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing LIME1 are readily searchable from our website. Different antibodies against the same target such as LIME1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.