|The Lysine, Acetylated n/a (Catalog #MBS6013224) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Lysine, Acetylated (Acetyl-Lysine) reacts with Bovine, C elegans, Canine, Chicken, Hamster, Human, Monkey, Mouse, Porcine, Rat, Xenopus0 and may cross-react with other species as described in the data sheet. MyBioSource\'s Lysine, Acetylated can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP).
Suitable for use in ELISA, Western Blot and Immunoprecipitation.
Dilution: ELISA-Peptide: 1:1000
Western Blot: 1:1000 Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Chromatin IP: 1:50. Researchers should empirically determine the suitability of the Lysine, Acetylated n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (1). Signaling resulting in acetylation/ deacetylation of histones, transcription factors and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation and apoptosis (2-6). Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin.
Immunogen: Synthetic peptide containing Acetylated-Lysine library. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Lysine, Acetylated are readily searchable from our website. Different antibodies against the same target such as Lysine, Acetylated may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.