anti-MAPK10 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-MAPK10 antibody; MAPK10;
The MAPK10 mapk10 (Catalog #MBS850734) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MAPK10 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s MAPK10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF), ELISA (EIA).WB: 1:500-1:2000
IF: 1:200-1:1000
ELISA: 1:10000. Researchers should empirically determine the suitability of the MAPK10 mapk10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MAPK10 mapk10 product has the following accession number(s) (GI #4506081) (NCBI Accession #NP_002744.1) (Uniprot Accession #P53779). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MAPK10 Antibody with the following immunoassay(s):
Testing Data (Figure 1. Western blot analysis using MAPK10 mouse mAb against NIH/3T3 (1) and SKN-SH (2) cell lysate.)
Testing Data #2 (Figure 2. Immunofluorescence staining of methanol-fixed A431 (left) and Hela (right) cells showing cytoplasmic and membrane localization.)
MAPK10. mitogen-activated protein kinase 10, also known as JNK3, JNK3A, PRKM10, p54bSAPK. Entrez Protein NP_002744. It is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Immunogen: Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MAPK10 are readily searchable from our website. Different antibodies against the same target such as MAPK10 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.