|The MARCH9 n/a (Catalog #MBS6008563) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MARCH9 (E3 Ubiquitin-protein Ligase MARCH9, Membrane-associated RING Finger Protein 9, Membrane-associated RING-CH Protein IX, MARCH-IX, RING Finger Protein 179, RNF179, FLJ36578, MARCH-IX) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s MARCH9 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the MARCH9 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MARCH9 n/a product has the following accession number(s) (GI #332330349) (NCBI Accession #AEE43934.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
HEGSSVYRIF KRWQAVNQQW KVLNYDKTKD IGGDAGGGTA GKSGPRNSRT GPTSGATSRP PAAQRMRTLL PQRCGYTILH LLGQLRPPDA RSSSHSGREV VMRVTT.
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MARCH9 belongs to the membrane associated RING-CH (MARCH) family of genes which encode a novel group of RING-type ubiquitin E3 ligases. It is the first ubiquitin E3 ligase to control expression of the critical cell adhesion molecule ICAM-1. The expression of the protein causes ubiquitination and downregulation of ICAM-1. A short alternative transcript of MARCH9 lacking the RING-CH domain, termed MARCH9 RINGless, is shown to act as a positive regulator of MARCH9 activity. Overexpression of the protein, leads to downregulation of cell surface major histocompatibility complex (MHC) class I and CD4. Human MARCH9 gene maps to chromosome 12q14.1.
Immunogen: Partial recombinant corresponding to aa240-346 from human MARCH9 (NP_612405) with GST tag. MW of the GST tag alone is 26kD. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MARCH9 are readily searchable from our website. Different antibodies against the same target such as MARCH9 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.